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apalutamide will lessen the extent or influence of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with medicine which can be CYP3A4 substrates can lead to lower publicity to those medications.fentanyl transmucosal and diazepam both of